Effect of substrate stiffness on differentiation of umbilical cord stem cells.
Acta Biochim Pol
; 59(2): 261-4, 2012.
Article
em En
| MEDLINE
| ID: mdl-22577624
ABSTRACT
Tissue formation and maintenance is regulated by various factors, including biological, physiological and physical signals transmitted between cells as well as originating from cell-substrate interactions. In our study, the osteogenic potential of mesenchymal stromal/stem cells isolated from umbilical cord Wharton's jelly (UC-MSCs) was investigated in relation to the substrate rigidity on polyacrylamide hydrogel (PAAM). Osteogenic differentiation of UC-MSCs was enhanced on stiff substrate compared to soft substrates, illustrating that the mechanical environment can play a role in differentiation of this type of cells. These results show that substrate stiffness can regulate UC-MSCs differentiation, and hence may have significant implications for design of biomaterials with appropriate mechanical properties for regenerative medicine.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Resinas Acrílicas
/
Diferenciação Celular
/
Hidrogéis
/
Geleia de Wharton
/
Células-Tronco Mesenquimais
Limite:
Humans
Idioma:
En
Revista:
Acta Biochim Pol
Ano de publicação:
2012
Tipo de documento:
Article