Juvenile, but not adult exposure to high-fat diet impairs relational memory and hippocampal neurogenesis in mice.
Hippocampus
; 22(11): 2095-100, 2012 Nov.
Article
em En
| MEDLINE
| ID: mdl-22593080
ABSTRACT
Increased consumption of high-fat diet (HFD) leads to obesity and adverse neurocognitive outcomes. Childhood and adolescence are important periods of brain maturation shaping cognitive function. These periods could consequently be particularly sensitive to the detrimental effects of HFD intake. In mice, juvenile and adulthood consumption of HFD induce similar morphometric and metabolic changes. However, only juvenile exposure to HFD abolishes relational memory flexibility, assessed after initial radial-maze concurrent spatial discrimination learning, and decreases neurogenesis. Our results identify a critical period of development covering adolescence with higher sensitivity to HFD-induced hippocampal dysfunction at both behavioral and cellular levels.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Sobrepeso
/
Neurogênese
/
Dieta Hiperlipídica
/
Hipocampo
/
Memória
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
En
Revista:
Hippocampus
Ano de publicação:
2012
Tipo de documento:
Article