Meningococcal polysaccharide vaccine failure in a patient with C7 deficiency and a decreased anti-capsular antibody response.
Hum Vaccin Immunother
; 8(5): 582-6, 2012 May.
Article
em En
| MEDLINE
| ID: mdl-22634438
ABSTRACT
A 20-y-old male presented with symptoms of meningococcal sepsis and died despite appropriate medical interventions. Blood cultures grew N. meningitidis serogroup Y. The patient had received the meningococcal quadrivalent (A,C,W-135,Y) polysaccharide vaccine 15 mo previously. Because the patient had a history of meningococcal meningitis at age 10, archived serum was obtained for further analysis. Complement component C7 was found to be deficient, and antibody levels to meningococcal polysaccharides were undetectable for two serogroups and low for the infecting serogroup 10 mo post-vaccination. This case highlights the fact that some individuals with terminal complement component deficiencies mount an impaired or short-lived response to vaccination with meningococcal capsular polysaccharides, and underscores the appropriateness of a more aggressive vaccination strategy in this patient population.
Texto completo:
1
Coleções:
01-internacional
Contexto em Saúde:
3_ND
Base de dados:
MEDLINE
Assunto principal:
Sepse
/
Vacinas Meningocócicas
/
Síndromes de Imunodeficiência
/
Infecções Meningocócicas
/
Anticorpos Antibacterianos
Limite:
Adult
/
Humans
/
Male
Idioma:
En
Revista:
Hum Vaccin Immunother
Ano de publicação:
2012
Tipo de documento:
Article