Damage- and pathogen-associated molecular patterns and alarmins: keys to sepsis?.
Eur Surg Res
; 48(4): 171-9, 2012.
Article
em En
| MEDLINE
| ID: mdl-22653136
ABSTRACT
The concept that sepsis is the result of an uncontrolled inflammatory response of the host's innate immune system towards invading pathogens has recently been challenged. Evidence is accumulating that, in addition, host-derived alarm molecules are released during sepsis- and trauma-associated cell death, thus triggering the host's immune response. The identification and characterization of exogenous as well as endogenous danger molecules allowed significant advances in our understanding of the pathophysiology of sepsis and may provide potential targets for therapeutic interventions.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Sepse
Tipo de estudo:
Risk_factors_studies
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Eur Surg Res
Ano de publicação:
2012
Tipo de documento:
Article