Transformation of primary myelofibrosis with 20q- in Philadelphia-positive acute lymphoblastic leukemia: case report and review of literature.
Pathol Res Pract
; 208(7): 420-3, 2012 Jul 15.
Article
em En
| MEDLINE
| ID: mdl-22658480
ABSTRACT
A 56-year-old male with chronic idiopathic myelofibrosis and cytogenetic finding of 20q- after a period of 10 months developed acute Philadelphia-positive lymphoblastic leukemia. Immunophenotyping of peripheral blood by flow cytometry showed HLA-DR, CD34, CD19, CD22, CD10, CD33, and CD11b positivity. Cytogenetic analysis revealed the presence of 20q- and Philadelphia chromosome t(9;22)(q34q11) at the time of disease transformation to ALL. The JAK2V617F mutation was not found. This is a very rare case of simultaneous presence of two cytogenetics abnormalities and evolution of primary idiopathic myelofibrosis to Philadelphia-positive acute lymphoblastic leukemia.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Cromossomos Humanos Par 20
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Cromossomo Filadélfia
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Transformação Celular Neoplásica
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Leucemia-Linfoma Linfoblástico de Células Precursoras
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Mielofibrose Primária
Limite:
Humans
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Male
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Middle aged
Idioma:
En
Revista:
Pathol Res Pract
Ano de publicação:
2012
Tipo de documento:
Article