Safety and immunogenicity of fully liquid DTaP5-IPV-Hib pediatric combination vaccine (Pediacel®) compared to DTaP3-HBV-IPV/Hib (Infanrix® Hexa) when coadministered with heptavalent pneumococcal conjugate vaccine (PCV7) as a booster at 11-18 months of age: a phase III, modified double-blind, randomized, controlled, multicenter study.
Vaccine
; 30(35): 5270-7, 2012 Jul 27.
Article
em En
| MEDLINE
| ID: mdl-22691430
ABSTRACT
This study compared the safety and immunogenicity of DTaP5-IPV-Hib vaccine (followed by monovalent hepatitis B vaccine [HBV]) and DTaP3-HBV-IPV/Hib vaccines, both coadministered with PCV7, as a fourth-dose booster in toddlers 11-18 months who had a hexavalent vaccine primary series. The fever rate within 4 days of DTaP5-IPV-Hib was noninferior to DTaP3-HBV-IPV/Hib. DTaP5-IPV-Hib induced a marked immune response and had a similar safety and immunogenicity profile compared with DTaP3-HBV-IPV/Hib. Fully liquid DTaP5-IPV-Hib can be used as a booster after a hexavalent vaccine primary series; where required, a fourth dose of monovalent HBV can be administered after DTaP5-IPV-Hib (NCT ID NCT00355654).
Texto completo:
1
Coleções:
01-internacional
Contexto em Saúde:
2_ODS3
/
4_TD
Base de dados:
MEDLINE
Assunto principal:
Vacina Antipólio de Vírus Inativado
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Vacina contra Difteria, Tétano e Coqueluche
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Vacinas Anti-Haemophilus
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Vacinas contra Difteria, Tétano e Coqueluche Acelular
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Vacinas Pneumocócicas
Tipo de estudo:
Clinical_trials
Limite:
Female
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Humans
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Infant
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Male
Idioma:
En
Revista:
Vaccine
Ano de publicação:
2012
Tipo de documento:
Article