Glioblastoma multiforme treatment with clinical trials for surgical resection (aminolevulinic acid).
Neurosurg Clin N Am
; 23(3): 371-7, 2012 Jul.
Article
em En
| MEDLINE
| ID: mdl-22748650
ABSTRACT
5-Aminolevulinic acid (5-ALA)-induced tumor fluorescence can be used to identify tissue for resection using an adapted operating microscope. A multi-institutional clinical trial comparing fluorescence-guided versus white light tumor resection reported significant improvement in completeness of resection and 6-month progression-free survival. The degree of 5-ALA-induced fluorescence correlates with histopathologic grade of tumor, degree of tumor cell infiltration, and proliferation indices. Quantitative methodologies for assessment of tissue fluorescence have significantly improved the ability to detect tumor tissue and intraoperative diagnostic performance. These developments extend the applicability of this technology to additional tumor histologies and provide the rationale for further instrumentation development.
Texto completo:
1
Coleções:
01-internacional
Contexto em Saúde:
1_ASSA2030
/
2_ODS3
/
6_ODS3_enfermedades_notrasmisibles
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Encefálicas
/
Fármacos Fotossensibilizantes
/
Glioblastoma
/
Ácido Aminolevulínico
Tipo de estudo:
Clinical_trials
Limite:
Humans
Idioma:
En
Revista:
Neurosurg Clin N Am
Ano de publicação:
2012
Tipo de documento:
Article