SLC33A1/AT-1 protein regulates the induction of autophagy downstream of IRE1/XBP1 pathway.
J Biol Chem
; 287(35): 29921-30, 2012 Aug 24.
Article
em En
| MEDLINE
| ID: mdl-22787145
ABSTRACT
One of the main functions of the unfolded protein response is to ensure disposal of large protein aggregates that accumulate in the lumen of the endoplasmic reticulum (ER) whereas avoiding, at least under nonlethal levels of ER stress, cell death. When tightly controlled, autophagy-dependent ER-associated degradation (ERAD(II)) allows the cell to recover from the transient accumulation of protein aggregates; however, when unchecked, it can be detrimental and cause autophagic cell death/type 2 cell death. Here we show that IRE1/XBP1 controls the induction of autophagy/ERAD(II) during the unfolded protein response by activating the ER membrane transporter SLC33A1/AT-1, which ensures continuous supply of acetyl-CoA into the lumen of the ER. Failure to induce AT-1 leads to widespread autophagic cell death. Mechanistically, the regulation of the autophagic process involves N(ε)-lysine acetylation of Atg9A.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Proteínas de Membrana Transportadoras
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Autofagia
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Fatores de Transcrição
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Proteínas Serina-Treonina Quinases
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Proteínas de Ligação a DNA
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Endorribonucleases
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Degradação Associada com o Retículo Endoplasmático
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Estresse do Retículo Endoplasmático
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Proteínas de Membrana
Limite:
Animals
/
Humans
Idioma:
En
Revista:
J Biol Chem
Ano de publicação:
2012
Tipo de documento:
Article