Detection and prognostic analysis of serum protein expression in esophageal squamous cell cancer.
Asian Pac J Cancer Prev
; 13(4): 1579-82, 2012.
Article
em En
| MEDLINE
| ID: mdl-22799370
ABSTRACT
OBJECTIVE:
To assess differences in serum proteins in esophageal squamous cell carcinoma patients.METHODS:
144 esophageal squamous cell carcinoma patients and 50 healthy volunteers were included in this study, with surface-enhanced laser desorption-ionization time-of-flight mass spectrometry and weak cation exchange magnetic beads. Follow-up allowed the relations between serum proteins and prognosis to be analyzed.RESULTS:
A total of 93 protein peaks were detected (molecular weight range 1500-3000), 10 demonstrating statistically significant differences. There were no differences in protein peaks between 92 patients with a survival more than 2 years and 52 patients with survival less than 2 years. There were two significantly different protein peaks between 45 stage II patients with a survival more than 2 years and 14 stage II patients with survival less than 2 years. There was one significantly different protein peak between 22 stage III patients with a survival more than 2 years and 29 stage III patients with survival less than 2 years.CONCLUSION:
Differences of serum proteins in esophageal squamous cell carcinoma are related to prognosis of patients. The protein fingerprint can be helpful for clinical diagnosis and treatment.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Esofágicas
/
Proteínas Sanguíneas
/
Carcinoma de Células Escamosas
/
Biomarcadores Tumorais
Tipo de estudo:
Diagnostic_studies
/
Prognostic_studies
Limite:
Adult
/
Aged
/
Humans
/
Middle aged
Idioma:
En
Revista:
Asian Pac J Cancer Prev
Ano de publicação:
2012
Tipo de documento:
Article