[Sleep and wakefulness regulation: molecular players]. / Régulation de la veille et du sommeil: les acteurs moléculaires.
Bull Acad Natl Med
; 195(7): 1551-65; discussion 1565, 2011 Oct.
Article
em Fr
| MEDLINE
| ID: mdl-22812160
ABSTRACT
By combining brain section/lesion studies and sleep analysis, neurophysiologists have identified the brain areas responsible for regulating sleep and wakefulness during the first half of the 20th century. Identification of the phenotypic nature of the neurons underlying the regulation of vigilance, as well as their anatomical and functional connections led to a theoretical model based on mutual inhibitory interactions between sleep-on neurons (namely GABAergic neurons of the hypothalamic preoptic region) and wake-on neurons (mainly monoaminergic and cholinergic neurons). In addition to the corresponding neurotransmitters (serotonin, acetylcholine and GABA), other neuroactive molecules that play key roles in sleep and wakefulness regulation have recently been discovered, leading to an updated model. Hypocretin, also known as orexin, is a key neuropeptide involved in the sleep disorder narcolepsy. Extensive characterization of the respective roles of these neurotransmitters has led to the identification of novel therapeutic targets for the treatment of sleep disorders. For example, blockade of hypocretin receptors has hypnotic effects.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Sono
/
Vigília
Limite:
Humans
Idioma:
Fr
Revista:
Bull Acad Natl Med
Ano de publicação:
2011
Tipo de documento:
Article