Total synthesis of (±)-pallambins C and D.

Xu, Xue-Song; Li, Zhen-Wu; Zhang, Yi-Jun; Peng, Xiao-Shui; Wong, Henry N C

Xu, Xue-Song; Li, Zhen-Wu; Zhang, Yi-Jun; Peng, Xiao-Shui; Wong, Henry N C.

Afiliação

Xu XS; Department of Chemistry, Centre of Novel Functional Molecules, Institute of Molecular Technology for Drug Discovery and Synthesis, and State Key Laboratory of Synthetic Chemistry, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong SAR, China.

Chem Commun (Camb) ; 48(68): 8517-9, 2012 Sep 04.

Article em En | MEDLINE | ID: mdl-22820708

ABSTRACT

ABSTRACT

The first total synthesis of (±)-pallambins C and D has been accomplished in a linear 38 step reaction from (±)-Wieland-Miescher ketone. The key conversions are featured as follows a Grob fragmentation-intramolecular aldol cyclization and a thiourea/palladium-catalyzed carbonylative annulation.

Assuntos

Diterpenos/síntese química; Aldeídos/química; Catálise; Ciclização; Diterpenos/química; Paládio/química; Estereoisomerismo; Tioureia/química

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Diterpenos Idioma: En Revista: Chem Commun (Camb) Ano de publicação: 2012 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google