Hyperglycemic effects of a periocular dexamethasone injection in diabetic patients after vitreoretinal surgery.
Biomed Environ Sci
; 25(3): 311-6, 2012 Jun.
Article
em En
| MEDLINE
| ID: mdl-22840582
ABSTRACT
OBJECTIVE:
To examine the hyperglycemic effects of periocular dexamethasone injection in type 2 diabetic patients after vitreoretinal surgery (VRS).METHODS:
This was a retrospective non-randomized controlled trial. Twenty consecutive hospitalized patients with type 2 diabetes and ocular inflammatory reaction after VRS were enrolled in this study. Ten patients received 2.5 mg dexamethasone and 10 patients received 5 mg dexamethasone. Fourteen consecutive type 2 diabetic patients without ocular inflammatory reaction after VRS were used as control group. We measured fasting blood glucose (FBG) and at 2 h after each meal (post prandial glucose, PBG; 0900, 1300, and 1900 h) after periocular dexamethasone injection. Differences among three groups were determined by q tests.RESULTS:
The PBG levels in both dexamethasone-treated groups started to increase within 5 h after injection (i.e., PBG at 1300 h), and were significantly increased at 1900 h after injection (P<0.05). BG levels were almost 2-fold higher than at baseline and compared with the control group. The BG values declined gradually by 24 h to 48 h after injection. There were no differences in BG levels between the two dexamethasone-treated groups (P>0.05), except for PBG at 1900 h on day 2 after injection (P<0.05).CONCLUSION:
Periocular dexamethasone injection can cause transient hyperglycemia in diabetic patients after VRS. BG monitoring should be performed following such injection.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Dexametasona
/
Diabetes Mellitus Tipo 2
/
Hiperglicemia
/
Anti-Inflamatórios
Tipo de estudo:
Observational_studies
Limite:
Humans
Idioma:
En
Revista:
Biomed Environ Sci
Ano de publicação:
2012
Tipo de documento:
Article