[The dynamics of the griseofulvin levels in the blood and skin of guinea pigs during its combined use with alpha-tocopherol]. / Dinamika soderzhaniia grizeoful'vina v krovi i kozhe morskikh svinok pri ego kompleksnom primenenii s al'fa-tokoferolom.
Vestn Dermatol Venerol
; (9): 15-6, 1990.
Article
em Ru
| MEDLINE
| ID: mdl-2284849
ABSTRACT
Experiments with 120 guinea pigs have revealed that skin griseofulvin levels depend on blood griseofulvin level and reduce after a prolonged (for 3-4 weeks) administration of the antibiotic in a dose of 30 mg/kg. Reduction of P-450 system enzymes activities achieved with alpha-tocopherol slows down griseofulvin biotransformation rate and significantly elevates its blood serum and skin concentrations.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Pele
/
Vitamina E
/
Griseofulvina
Limite:
Animals
Idioma:
Ru
Revista:
Vestn Dermatol Venerol
Ano de publicação:
1990
Tipo de documento:
Article