"Clicked" sugar-curcumin conjugate: modulator of amyloid-ß and tau peptide aggregation at ultralow concentrations.

ABSTRACT

The synthesis of a water/plasma soluble, noncytotoxic, "clicked" sugar-derivative of curcumin with amplified bioefficacy in modulating amyloid-ß and tau peptide aggregation is presented. Curcumin inhibits amyloid-ß and tau peptide aggregation at micromolar concentrations; the sugar-curcumin conjugate inhibits Aß and tau peptide aggregation at concentrations as low as 8 nM and 0.1 nM, respectively. In comparison to curcumin, this conveniently synthesized Alzheimer's drug candidate is a more powerful antioxidant.