Enteric-coated mycophenolate sodium immunosuppression in renal transplant patients: efficacy and dosing.
Transplant Rev (Orlando)
; 26(4): 233-40, 2012 Oct.
Article
em En
| MEDLINE
| ID: mdl-22863029
ABSTRACT
Mycophenolate mofetil (MMF), a mycophenolic acid (MPA) formulation, has improved both short- and long-term outcomes following renal transplantation, but is often associated with gastrointestinal (GI) complications that can lead to dose reduction or discontinuation, potentially jeopardizing patient outcomes. Enteric-coated mycophenolate sodium (EC-MPS) delivers equivalent MPA exposure to MMF and offers the potential to reduce GI burden (while maintaining patient safety). Here we review the efficacy of EC-MPS compared with MMF in renal transplant patients in terms of biopsy-proven acute rejection and graft loss, and examine the use of EC-MPS in newer regimens such as intensified dosing and calcineurin inhibitor minimization.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Transplante de Rim
/
Rejeição de Enxerto
/
Imunossupressores
/
Ácido Micofenólico
Limite:
Humans
Idioma:
En
Revista:
Transplant Rev (Orlando)
Ano de publicação:
2012
Tipo de documento:
Article