Activation of B cells by non-canonical helper signals.
EMBO Rep
; 13(9): 798-810, 2012 Sep.
Article
em En
| MEDLINE
| ID: mdl-22868664
ABSTRACT
Cognate interaction between T and B lymphocytes of the adaptive immune system is essential for the production of high-affinity antibodies against microbes, and for the establishment of long-term immunological memory. Growing evidence shows that--in addition to presenting antigens to T and B cells--macrophages, dendritic cells and other cells of the innate immune system provide activating signals to B cells, as well as survival signals to antibody-secreting plasma cells. Here, we discuss how these innate immune cells contribute to the induction of highly diversified and temporally sustained antibody responses, both systemically and at mucosal sites of antigen entry.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Linfócitos B
/
Ativação Linfocitária
/
Linfócitos T Auxiliares-Indutores
/
Células T Matadoras Naturais
Limite:
Animals
/
Humans
Idioma:
En
Revista:
EMBO Rep
Ano de publicação:
2012
Tipo de documento:
Article