Cycle control on low-dose oral contraceptives: a comparative trial.
Contraception
; 42(3): 253-62, 1990 Sep.
Article
em En
| MEDLINE
| ID: mdl-2289388
ABSTRACT
Cycle control was studied comparing the monophasic oral contraceptive Loestrin with three low-dose phasic preparations (Triphasil, Ortho 10/11 and Ortho 7/7/7) in 391 women of whom 300 completed 6 cycles. Loestrin subjects had a rate of occurrence (31% of cycles) for intermenstrual bleeding (IMB) comparable to the rates for subjects on the phasic preparations (36%, 37% and 37%, respectively). Triphasil subjects had lower rates than the Ortho 10/11 and Ortho 7/7/7 subjects (p less than 0.01) in cycle one when all subjects were analyzed and in pre-study users when continuing menstrual flow (CMF) episodes were not included as IMB. IMB was a cause for dropping out of the study in 7% of subjects who were evenly distributed between groups. There were no differences between groups for BTB when perceived by subjects as a side effect. Spotting was perceived as a side effect more often with Ortho 10/11 and Ortho 7/7/7 use than with Triphasil (p less than 0.01). Loestrin, Ortho 10/11 and Ortho 7/7/7 subjects were more likely to report amenorrhea (p less than 0.001) and less likely to report leg cramps (p less than 0.01) compared to those on Triphasil. Triphasil subjects were less likely to report acne than subjects on Ortho 7/7/7 (p less than 0.01).
Palavras-chave
Amenorrhea; Americas; Bleeding; Canada; Comparative Studies; Contraception; Contraceptive Methods; Contraceptive Methods--side effects; Data Analysis; Data Collection; Developed Countries; Diseases; Family Planning; Incidence; Measurement; Menstrual Cycle; Menstruation; Menstruation Disorders; Metrorrhagia; North America; Northern America; Oral Contraceptives; Oral Contraceptives, Low-dose; Oral Contraceptives, Low-dose--side effects; Oral Contraceptives--side effects; Reproduction; Research Methodology; Signs And Symptoms; Studies
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Anticoncepcionais Orais Sintéticos
/
Ciclo Menstrual
Tipo de estudo:
Clinical_trials
Limite:
Adolescent
/
Adult
/
Female
/
Humans
Idioma:
En
Revista:
Contraception
Ano de publicação:
1990
Tipo de documento:
Article