Localized delivery of dexamethasone from electrospun fibers reduces the foreign body response.
Biomacromolecules
; 13(10): 3031-8, 2012 Oct 08.
Article
em En
| MEDLINE
| ID: mdl-22920794
ABSTRACT
Synthetic scaffolds are crucial to applications in regenerative medicine; however, the foreign body response can impede regeneration and may lead to failure of the implant. Herein we report the development of a tissue engineering scaffold that allows attachment and proliferation of regenerating cells while reducing the foreign body response by localized delivery of an anti-inflammatory agent. Electrospun fibers composed of poly(l-lactic) acid (PLLA) and poly(ε-caprolactone) (PCL) were prepared with and without the steroid anti-inflammatory drug, dexamethasone. Analysis of subcutaneous implants demonstrated that the PLLA fibers encapsulating dexamethasone evoked a less severe inflammatory response than the other fibers examined. They also displayed a controlled release of dexamethasone over a period of time conducive to tissue regeneration and allowed human mesenchymal stem cells to adhere to and proliferate on them in vitro. These observations demonstrate their potential as a building block for tissue engineering scaffolds.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Materiais Biocompatíveis
/
Dexametasona
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Reação a Corpo Estranho
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Células-Tronco Mesenquimais
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Anti-Inflamatórios
Limite:
Humans
Idioma:
En
Revista:
Biomacromolecules
Ano de publicação:
2012
Tipo de documento:
Article