D6: the 'crowd controller' at the immune gateway.
Trends Immunol
; 34(1): 7-12, 2013 Jan.
Article
em En
| MEDLINE
| ID: mdl-22921835
ABSTRACT
The chemokine-scavenging receptor, D6, is reported to regulate resolution of inflammatory responses. However, recent data also point to an unanticipated role for D6 in coordinating innate and adaptive immune responses. Here, we propose that D6 is essential for preventing inflammatory leukocyte association with lymphatic vasculature. In the absence of D6, inappropriate inflammatory leukocyte accumulation around lymphatic endothelium congests the lymphatic system, impairing fluid and cellular flow from inflamed sites to lymph nodes and reducing efficiency of antigen presentation. Thus, the inability of D6-deficient mice to resolve inflammation may be a byproduct of impaired fluid drainage from inflamed sites and thus we provide a model unifying D6 function in innate and adaptive immune responses.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Receptores CCR10
/
Sistema Imunitário
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Trends Immunol
Ano de publicação:
2013
Tipo de documento:
Article