TAK1, more than just innate immunity.
IUBMB Life
; 64(10): 825-34, 2012 Oct.
Article
em En
| MEDLINE
| ID: mdl-22941947
ABSTRACT
Transforming growth factor ß-activated kinase 1 (TAK1) is a key regulator of the innate immunity and the proinflammatory signaling pathway. In response to interleukin-1, tumor necrosis factor-α, and toll-like receptor agonists, it mediates the activation of the nuclear factor κB (NF-κB), c-Jun N-terminal kinase (JNK), and p38 pathways. In addition, TAK1 plays a central role in adaptive immunity, in which it mediates signaling from T- and B-cell receptors. This review will focus on recent developments and also examine the regulation of TAK1 in response to a diverse range of other stimuli including DNA damage, transforming growth factor-ß, Wnt, osmotic stress, and hypoxia.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Transdução de Sinais
/
Regulação da Expressão Gênica
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MAP Quinase Quinase Quinases
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Imunidade Adaptativa
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Imunidade Inata
Limite:
Animals
/
Humans
Idioma:
En
Revista:
IUBMB Life
Ano de publicação:
2012
Tipo de documento:
Article