Nuclear receptor coactivator RAC3 inhibits autophagy.
Cancer Sci
; 103(12): 2064-71, 2012 Dec.
Article
em En
| MEDLINE
| ID: mdl-22957814
ABSTRACT
RAC3 is an oncogene naturally overexpressed in several tumors. Besides its role as coactivator, it can exert several protumoral cytoplasmic actions. Autophagy was found to act either as a tumor suppressor during the early stages of tumor development, or as a protector of the tumor cell in later stages under hypoxic conditions. We found that RAC3 overexpression inhibits autophagy when induced by starvation or rapamycin and involves RAC3 nuclear translocation-dependent and -independent mechanisms. Moreover, hypoxia inhibits the RAC3 gene expression leading to the autophagy process, allowing tumor cells to survive until angiogenesis occurs. The interplay between RAC3, hypoxia, and autophagy could be an important mechanism for tumor progression and a good target for a future anticancer therapy.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Autofagia
/
Proteínas rac de Ligação ao GTP
Limite:
Humans
Idioma:
En
Revista:
Cancer Sci
Ano de publicação:
2012
Tipo de documento:
Article