Low-dose radiation hyper-radiosensitivity in multicellular tumour spheroids.
Br J Radiol
; 85(1018): 1398-406, 2012 Oct.
Article
em En
| MEDLINE
| ID: mdl-22972973
ABSTRACT
OBJECTIVE:
We propose and study a new model aimed at describing the low-dose hyper-radiosensitivity phenomenon appearing in the survival curves of different cell lines.METHODS:
The model uses the induced repair assumption, considering that the critical dose at which this mechanism begins to act varies from cell to cell in a given population. The model proposed is compared with the linear-quadratic model and the modified linear-quadratic model, which is commonly used in literature and in which the induced repair is taken into account in a heuristic way. The survival curve for the MCF-7 line of human breast cancer is measured at low absorbed doses and the uncertainties in these doses are estimated using thermoluminiscent dosemeters.RESULTS:
It is shown that these multicellular spheroids present low-dose hyper-radiosensitivity. The new model permits an accurate description of the data of two human cell lines (previously published) and of the multicellular spheroids of the MCF-7 line here measured.CONCLUSION:
The model shows enough flexibility to account for data with very different characteristics and considers in a faithful way the hypothesis of the repair induction.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Tolerância a Radiação
/
Neoplasias da Mama
/
Esferoides Celulares
Tipo de estudo:
Prognostic_studies
Limite:
Female
/
Humans
Idioma:
En
Revista:
Br J Radiol
Ano de publicação:
2012
Tipo de documento:
Article