Increased number of activated T cells in lymphocyte subsets of maltreated children: data from a pilot study.
J Psychosom Res
; 73(4): 313-8, 2012 Oct.
Article
em En
| MEDLINE
| ID: mdl-22980539
ABSTRACT
OBJECTIVE:
Maltreatment in childhood has been related to enduring changes in the immune system of adults, such as increased cell-mediated immune response.PURPOSE:
Due to the lack of data in children, this study examined lymphocyte subset numbers and distribution during youth.METHODS:
In 27 cases of 42 healthy but maltreated children, fully participating at follow-up 1-3years after the intervention of child protection team, and 19 cases of previously matched controls, analysis of blood samples by fluorescent activated cell sorter was consented.RESULTS:
With regard to age references, total lymphocyte counts were aberrant in maltreated children but not in controls. When compared to controls, the percentages and absolute numbers of activated (HLA-DR+) CD4+helper and CD8+cytotoxic T cells were significantly higher in maltreated children.CONCLUSIONS:
According to the typical distribution of HLA-DR+cells we assumed an increased stimulated cell-mediated immune function in maltreated children.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ativação Linfocitária
/
Linfócitos T
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Maus-Tratos Infantis
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Subpopulações de Linfócitos T
Limite:
Adolescent
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Child
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Child, preschool
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Female
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Humans
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Male
Idioma:
En
Revista:
J Psychosom Res
Ano de publicação:
2012
Tipo de documento:
Article