Interleukin-15 is a major regulator of the cell-microenvironment interactions in human renal homeostasis.
Cytokine Growth Factor Rev
; 24(1): 13-22, 2013 Feb.
Article
em En
| MEDLINE
| ID: mdl-22981349
ABSTRACT
Experiments in IL-15(-/-) and IL-15Rα(-/-) mice show that intra-renal IL-15, through IL-15Rα behaves as an epithelial survival factor. Recent data highlight new functions of IL-15 in renal homeostasis mediated by IL-15Rγ (CD132). Indeed, in CD132+ renal epithelial tubular cells IL-15 preserves E-cadherin expression inhibiting epithelial-mesenchymal transition (EMT). By contrast, during allograft rejection, the increased intra-graft IL-15 expression favors tubular destruction facilitating the intraepithelial recruitment of CD8 T cells expressing the E-cadherin ligand CD103. In renal cancer, loss of CD132 by epithelial cells defines a tumoral microenvironment where IL-15 triggers E-cadherin down-regulation and EMT. Finally, in CD132+ renal cancer stem cells IL-15 induces the generation of non-tumorigenic epithelial cells sensitive to cytotoxic drugs. These findings are discussed in the light of IL-15-based immunotherapy for renal cancer.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Interleucina-15
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Subunidade alfa de Receptor de Interleucina-15
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Homeostase
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Rim
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Neoplasias Renais
Limite:
Animals
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Humans
Idioma:
En
Revista:
Cytokine Growth Factor Rev
Ano de publicação:
2013
Tipo de documento:
Article