Autonomous and nonautonomous roles of Hedgehog signaling in regulating limb muscle formation.
Genes Dev
; 26(18): 2088-102, 2012 Sep 15.
Article
em En
| MEDLINE
| ID: mdl-22987639
ABSTRACT
Muscle progenitor cells migrate from the lateral somites into the developing vertebrate limb, where they undergo patterning and differentiation in response to local signals. Sonic hedgehog (Shh) is a secreted molecule made in the posterior limb bud that affects patterning and development of multiple tissues, including skeletal muscles. However, the cell-autonomous and non-cell-autonomous functions of Shh during limb muscle formation have remained unclear. We found that Shh affects the pattern of limb musculature non-cell-autonomously, acting through adjacent nonmuscle mesenchyme. However, Shh plays a cell-autonomous role in maintaining cell survival in the dermomyotome and initiating early activation of the myogenic program in the ventral limb. At later stages, Shh promotes slow muscle differentiation cell-autonomously. In addition, Shh signaling is required cell-autonomously to regulate directional muscle cell migration in the distal limb. We identify neuroepithelial cell transforming gene 1 (Net1) as a downstream target and effector of Shh signaling in that context.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Transdução de Sinais
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Diferenciação Celular
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Músculo Esquelético
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Extremidades
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Proteínas Hedgehog
Limite:
Animals
Idioma:
En
Revista:
Genes Dev
Ano de publicação:
2012
Tipo de documento:
Article