Baclofen does not protect against cerebral ischemia in rats.
Stroke
; 21(1): 138-40, 1990 Jan.
Article
em En
| MEDLINE
| ID: mdl-2300981
ABSTRACT
Presynaptic release of glutamate into the extracellular compartment and activation of receptor-operated calcium channels may contribute to ischemic neuronal damage. We evaluated the effect of baclofen, a selective inhibitor of presynaptic glutamate release, on mortality, working memory, and light microscopic hippocampal and cortical damage in the four-vessel occlusion model of cerebral ischemia using 64 male Wistar rats. Baclofen (10 mg/kg i.p.) given 1 hour before and 30-60 minutes after 20 minutes of global ischemia did not lessen mortality, prevent ischemic cellular damage, or significantly improve working memory compared with no treatment. We conclude that preischemic and postischemic administration of baclofen does not protect neurons from ischemic injury.
Buscar no Google
Coleções:
01-internacional
Contexto em Saúde:
6_ODS3_enfermedades_notrasmisibles
Base de dados:
MEDLINE
Assunto principal:
Baclofeno
/
Isquemia Encefálica
Limite:
Animals
Idioma:
En
Revista:
Stroke
Ano de publicação:
1990
Tipo de documento:
Article