TBX2 expression is regulated by PAX3 in the melanocyte lineage.
Pigment Cell Melanoma Res
; 26(1): 67-77, 2013 Jan.
Article
em En
| MEDLINE
| ID: mdl-23020925
ABSTRACT
The paired box homeotic gene 3 (PAX3) is a crucial regulator for the maintenance of melanocytic progenitor cells and has a poorly defined role in melanoma. To understand how PAX3 affects melanocyte and melanoma proliferation, we identified potential PAX3 downstream targets through gene expression profiling. Here, we identify T-box 2 (TBX2), a key developmental regulator of cell identity and an antisenescence factor in melanoma, as a directly regulated PAX3 target. We also found that TBX2 is involved in the survival of melanoma cells and is overexpressed in some melanoma specimens. The identification of TBX2 as a target for PAX3 provides a key insight into how PAX3 may contribute to melanoma evolution and may provide opportunities for prosenescence therapeutic intervention aimed at disrupting the ability of PAX3 to regulate TBX2.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Regulação da Expressão Gênica
/
Linhagem da Célula
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Proteínas com Domínio T
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Fatores de Transcrição Box Pareados
/
Melanócitos
Tipo de estudo:
Prognostic_studies
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Pigment Cell Melanoma Res
Ano de publicação:
2013
Tipo de documento:
Article