Regulation of synaptojanin 2 5'-phosphatase activity by Src.
Cell Adh Migr
; 6(6): 518-25, 2012.
Article
em En
| MEDLINE
| ID: mdl-23076136
ABSTRACT
Synaptojanin 2 (SYNJ2) is a phosphatidylinositol (PI) phosphatase that controls two distinct functions, clathrin-mediated endocytosis and tumor cell invadopodia formation and invasion. Here, we identify a number of novel SYNJ2 binding partners, several of which have previously been shown to be necessary for invadopodia formation or clathrin-mediated endocytosis. We focus on Src family kinases. We found that Src phosphorylates SYNJ2 on Tyr ( 490) , thereby stimulating SYNJ2 5'-phosphatase activity in vitro. We also provide evidence that Src-mediated phosphorylation of SYNJ2 contributes to invadopodia formation.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Monoéster Fosfórico Hidrolases
/
Vesículas Revestidas por Clatrina
/
Cortactina
/
Proteínas Proto-Oncogênicas c-fyn
Limite:
Humans
Idioma:
En
Revista:
Cell Adh Migr
Ano de publicação:
2012
Tipo de documento:
Article