Improved preparation of methyl bis(2,2,2-trifluoroethoxy)-bromophosphonoacetate for the stereoselective synthesis of (E)-α-bromoacrylates.
Chem Pharm Bull (Tokyo)
; 61(1): 108-10, 2013.
Article
em En
| MEDLINE
| ID: mdl-23080299
ABSTRACT
We have established an efficient method for preparing methyl bis(2,2,2-trifluoroethoxy)bromophosphonoacetate, which we developed for the stereoselective synthesis of (E)-α-bromoacrylates. This improved method enables the reagent to be prepared reproducibly in one step from methyl bis(2,2,2-trifluoroethoxy)phosphonoacetate.
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MEDLINE
Assunto principal:
Ácido Fosfonoacéticos
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Idioma:
En
Revista:
Chem Pharm Bull (Tokyo)
Ano de publicação:
2013
Tipo de documento:
Article