Investigating transcriptional states at single-cell-resolution.
Curr Opin Biotechnol
; 24(1): 69-78, 2013 Feb.
Article
em En
| MEDLINE
| ID: mdl-23084076
ABSTRACT
Gene expression analysis at single-cell-resolution is a powerful tool for uncovering individual cell differences within heterogeneous cell populations and complex tissues, which can provide invaluable insights into the extent of gene expression variability. Multi-dimensional information of gene expression at the level of the individual cell can help to identify distinct and rare molecular cell 'states' within populations and aid in unravelling genetic regulatory circuits. Gene expression analysis at the single-cell-level will also enhance our understanding of the molecular basis of aberrant cell states and disease development and holds great promise for the advancement of personalized medicine. We present approaches that provide large-scale views of gene expression at the level of the individual cell.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Transcrição Gênica
/
Perfilação da Expressão Gênica
/
Análise de Célula Única
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Curr Opin Biotechnol
Ano de publicação:
2013
Tipo de documento:
Article