Purinergic P2X receptors and diabetic neuropathic pain.
Sheng Li Xue Bao
; 64(5): 531-42, 2012 Oct 25.
Article
em En
| MEDLINE
| ID: mdl-23090494
ABSTRACT
Diabetic peripheral neuropathy (DPN), one of the most common chronic complications of diabetes, is characterized by allodynia, hyperalgesia and spontaneous pain. Chinese epidemiological studies have shown that at least 25% diabetic patients suffered from painful DPN, which compromises patients' daily functioning and becomes a major health care problem. Although the pathogenesis of painful DPN is not fully understood and current treatment options are very limited, research in the field has advanced our understanding on the mechanism of painful DPN in the past Decade of Pain Research and Control. This review will mainly focus on evaluation of current diabetic animal models, possible molecular pathways and available therapies, with an emphasis on roles of purinergic receptor and its signaling transduction pathways. Common therapies address one or two DPN symptoms, while others offer wider symptom control, presumably by targeting pathophysiological mechanisms of DPN. Purinergic receptor signaling transduction pathways might become potential targets for treatment for painful DPN.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Dor
/
Neuropatias Diabéticas
/
Receptores Purinérgicos P2X
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Sheng Li Xue Bao
Ano de publicação:
2012
Tipo de documento:
Article