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Identification and validation of urinary metabolite biomarkers for major depressive disorder.
Zheng, Peng; Wang, Ying; Chen, Liang; Yang, Deyu; Meng, Huaqing; Zhou, Dezhi; Zhong, Jiaju; Lei, Yang; Melgiri, N D; Xie, Peng.
Afiliação
  • Zheng P; Department of Neurology, The First Affiliated Hospital, Chongqing Medical University, Chongqing, China 400016.
Mol Cell Proteomics ; 12(1): 207-14, 2013 Jan.
Article em En | MEDLINE | ID: mdl-23111923
Major depressive disorder (MDD) is a widespread and debilitating mental disorder. However, there are no biomarkers available to aid in the diagnosis of this disorder. In this study, a nuclear magnetic resonance spectroscopy-based metabonomic approach was employed to profile urine samples from 82 first-episode drug-naïve depressed subjects and 82 healthy controls (the training set) in order to identify urinary metabolite biomarkers for MDD. Then, 44 unselected depressed subjects and 52 healthy controls (the test set) were used to independently validate the diagnostic generalizability of these biomarkers. A panel of five urinary metabolite biomarkers-malonate, formate, N-methylnicotinamide, m-hydroxyphenylacetate, and alanine-was identified. This panel was capable of distinguishing depressed subjects from healthy controls with an area under the receiver operating characteristic curve (AUC) of 0.81 in the training set. Moreover, this panel could classify blinded samples from the test set with an AUC of 0.89. These findings demonstrate that this urinary metabolite biomarker panel can aid in the future development of a urine-based diagnostic test for MDD.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transtorno Depressivo Maior / Metaboloma / Metabolômica Tipo de estudo: Diagnostic_studies / Prognostic_studies Limite: Adult / Female / Humans / Male Idioma: En Revista: Mol Cell Proteomics Ano de publicação: 2013 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transtorno Depressivo Maior / Metaboloma / Metabolômica Tipo de estudo: Diagnostic_studies / Prognostic_studies Limite: Adult / Female / Humans / Male Idioma: En Revista: Mol Cell Proteomics Ano de publicação: 2013 Tipo de documento: Article