The transcriptional regulator lola is required for stem cell maintenance and germ cell differentiation in the Drosophila testis.
Dev Biol
; 373(2): 310-21, 2013 Jan 15.
Article
em En
| MEDLINE
| ID: mdl-23159836
ABSTRACT
Stem cell behavior is regulated by extrinsic signals from specialized microenvironments, or niches, and intrinsic factors required for execution of context-appropriate responses to niche signals. Here we show that function of the transcriptional regulator longitudinals lacking (lola) is required cell autonomously for germline stem cell and somatic cyst stem cell maintenance in the Drosophila testis. In addition, lola is also required for proper execution of key developmental transitions during male germ cell differentiation, including the switch from transit amplifying progenitor to spermatocyte growth and differentiation, as well as meiotic cell cycle progression and spermiogenesis. Different lola isoforms, each having unique C-termini and zinc finger domains, may control different aspects of proliferation and differentiation in the male germline and somatic cyst stem cell lineages.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Espermatozoides
/
Células-Tronco
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Testículo
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Fatores de Transcrição
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Diferenciação Celular
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Proteínas de Drosophila
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Drosophila melanogaster
Limite:
Animals
Idioma:
En
Revista:
Dev Biol
Ano de publicação:
2013
Tipo de documento:
Article