Human cord blood γδ T cells expressing public Vγ2 chains dominate the response to bisphosphonate plus interleukin-15.
Immunology
; 138(4): 346-60, 2013 Apr.
Article
em En
| MEDLINE
| ID: mdl-23181340
ABSTRACT
Compared with adults, the circulating Vγ2Vδ2 T-cell population in cord blood is present at low levels and does not show the strong bias for Vγ2-Jγ1.2 rearrangements. These features may be a result of limited exposure to stimulatory phosphoantigens, lack of T-cell-derived interleukin-2 (IL-2) or both. In cord blood mononuclear cell cultures, a single round of stimulation, using aminobisphosphonates to elevate phosphoantigen levels, resulted in expansion of adult-like Vγ2 chains and accumulation of memory cells with cytotoxic potential. Selection was similar using IL-2 or myeloid-derived IL-15. The Vγ2Vδ2 T cells present in neonates are capable of generating potent immune responses even when relying on IL-15.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Linfócitos T Citotóxicos
/
Receptores de Antígenos de Linfócitos T gama-delta
/
Alendronato
/
Interleucina-15
/
Sangue Fetal
Limite:
Adult
/
Humans
Idioma:
En
Revista:
Immunology
Ano de publicação:
2013
Tipo de documento:
Article