Intratumoral TNFα improves immunotherapy.
Oncoimmunology
; 1(8): 1395-1397, 2012 Nov 01.
Article
em En
| MEDLINE
| ID: mdl-23243605
ABSTRACT
Solid tumors are frequently resistant to immunotherapy. We demonstrated that low-dose tumor necrosis factorα (TNFα), when directly targeted to the tumor environment, exerts dual effects by improving vessel functionality and activating immune cells. This vascular remodeling in an inflammatory context enhances active immunotherapy and promotes tumor regression.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Revista:
Oncoimmunology
Ano de publicação:
2012
Tipo de documento:
Article