Dual functions of Insig proteins in cholesterol homeostasis.
Lipids Health Dis
; 11: 173, 2012 Dec 18.
Article
em En
| MEDLINE
| ID: mdl-23249523
ABSTRACT
The molecular mechanism of how cells maintain cholesterol homeostasis has become clearer for the understanding of complicated association between sterol regulatory element-binding proteins (SREBPs), SREBP cleavage-activating protein (SCAP), 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMG-CoA reductase) and Insuin induced-genes (Insigs). The pioneering researches suggested that SREBP activated the transcription of genes encoding HMG-CoA reductase and all of the other enzymes involved in the synthesis of cholesterol and lipids. However, SREBPs can not exert their activities alone, they must form a complex with another protein, SCAP in the endoplasmic reticulum (ER) and translocate to Golgi. Insigs are sensors and mediators that regulate cholesterol homeostasis through binding to SCAP and HMG-CoA reductase in diverse tissues such as adipose tissue and liver, as well as the cultured cells. In this article, we aim to review on the dual functions of Insig protein family in cholesterol homeostasis.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Colesterol
/
Peptídeos e Proteínas de Sinalização Intracelular
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Hidroximetilglutaril-CoA Redutases
/
Insulina
/
Proteínas de Membrana
Limite:
Humans
Idioma:
En
Revista:
Lipids Health Dis
Ano de publicação:
2012
Tipo de documento:
Article