[Relationship between pesticide exposure and adverse pregnancy outcomes among famers: a meta-analysis].

ABSTRACT

OBJECTIVE: To analyze the relationship between pesticide exposure and adverse pregnancy outcomes in famers. METHODS: A search was conducted to collect the articles about the relationship between pesticide exposure and adverse pregnancy outcomes published worldwide from 1990 to February 2012. Meta-analysis was performed on the collected articles using RevMan 4.2 software. RESULTS: Twelve articles were collected. Compared with the controls, the pesticide-exposed famers showed a combined odds ratio (OR) for spontaneous abortion of 1.52 (95%CI 1.04 ∼ 2.21; P = 0.03), a combined OR for premature birth of 1.33 (95%CI 1.09 ∼ 1.61; P = 0.005), a combined OR for dead fetus of 1.22 (95%CI 1.16 ∼ 1.29; P < 0.01), a combined OR for stillbirth of 1.90 (95%CI 0.58 ∼ 6.28; P = 0.29), a combined OR for birth defect of 2.02 (95%CI 0.84 - 4.69; P = 0.12), a combined OR for low birth weight of 1.62 (95%CI 0.60 ∼ 4.39; P = 0.34), a combined OR for neonatal death of 2.18 (95%CI 0.54 ∼ 8.88; P = 0.28), and a combined OR for delayed conception of 1.43 (95%CI 0.93 ∼ 2.18; P = 0.1). Pesticide exposure increased the risks for spontaneous abortion, premature birth, and dead fetus, but was not significantly associated with stillbirth, birth defect, low birth weight, neonatal death, and delayed conception. CONCLUSION: Pesticide exposure can cause adverse pregnancy outcomes in farmers, increasing the risks of spontaneous abortion, premature birth, and dead fetus.