Recent advances in understanding GLP-1R (glucagon-like peptide-1 receptor) function.
Biochem Soc Trans
; 41(1): 172-9, 2013 Feb 01.
Article
em En
| MEDLINE
| ID: mdl-23356279
ABSTRACT
Type 2 diabetes is a major global health problem and there is ongoing research for new treatments to manage the disease. The GLP-1R (glucagon-like peptide-1 receptor) controls the physiological response to the incretin peptide, GLP-1, and is currently a major target for the development of therapeutics owing to the broad range of potential beneficial effects in Type 2 diabetes. These include promotion of glucose-dependent insulin secretion, increased insulin biosynthesis, preservation of ß-cell mass, improved peripheral insulin sensitivity and promotion of weight loss. Despite this, our understanding of GLP-1R function is still limited, with the desired spectrum of GLP-1R-mediated signalling yet to be determined. We review the current understanding of GLP-1R function, in particular, highlighting recent contributions in the field on allosteric modulation, probe-dependence and ligand-directed signal bias and how these behaviours may influence future drug development.
Texto completo:
1
Coleções:
01-internacional
Contexto em Saúde:
2_ODS3
Base de dados:
MEDLINE
Assunto principal:
Receptores de Glucagon
Limite:
Humans
Idioma:
En
Revista:
Biochem Soc Trans
Ano de publicação:
2013
Tipo de documento:
Article