Deciphering supportive treatment strategies for toxic epidermal necrolysis.
Curr Drug Saf
; 7(5): 361-6, 2012 Nov 01.
Article
em En
| MEDLINE
| ID: mdl-23373547
ABSTRACT
Toxic epidermal necrolysis (TEN) is a dreadful life-threatening syndrome typically induced by an adverse drug reaction. This condition is characterized by the sudden and extensive destruction of the epidermis. The patient should be promptly addressed to a burn unit where three types of treatment should be administered, namely, (a) specific topical care of the bullous/eroded skin areas, (b) systemic anti-apoptotic/necrotic treatments, and (c) supportive care preventing secondary internal organ failures. This latter aspect is covered by the present review and focuses on (a) early withdrawal of the causative drug, (b) airway management, (c) hydro-electrolytic control, (d) nutritional support, (e) antibiotherapy, (f) prevention of venous thrombosis and gastroduodenal ulcers, and (g) analgesia and anesthesia.
Buscar no Google
Coleções:
01-internacional
Contexto em Saúde:
1_ASSA2030
/
2_ODS3
Base de dados:
MEDLINE
Assunto principal:
Síndrome de Stevens-Johnson
Limite:
Humans
Idioma:
En
Revista:
Curr Drug Saf
Ano de publicação:
2012
Tipo de documento:
Article