Evaluating evolutionary models of stress-induced mutagenesis in bacteria.
Nat Rev Genet
; 14(3): 221-7, 2013 03.
Article
em En
| MEDLINE
| ID: mdl-23400102
ABSTRACT
Increased mutation rates under stress allow bacterial populations to adapt rapidly to stressors, including antibiotics. Here we evaluate existing models for the evolution of stress-induced mutagenesis and present a new model arguing that it evolves as a result of a complex interplay between direct selection for increased stress tolerance, second-order selection for increased evolvability and genetic drift. Further progress in our understanding of the evolutionary biology of stress and mutagenesis will require a more detailed understanding both of the patterns of stress encountered by bacteria in nature and of the mutations that are produced under stress.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Estresse Fisiológico
/
Bactérias
/
Mutagênese
/
Evolução Molecular
/
Modelos Genéticos
Idioma:
En
Revista:
Nat Rev Genet
Ano de publicação:
2013
Tipo de documento:
Article