Identification of a new tadalafil analogue found in a dietary supplement.
Food Addit Contam Part A Chem Anal Control Expo Risk Assess
; 30(4): 621-6, 2013.
Article
em En
| MEDLINE
| ID: mdl-23419124
ABSTRACT
A new tadalafil analogue, acetaminotadalafil, was detected by HPLC in a bulk powder that is being used as an ingredient formanufacturing dietary supplements. The analogue was isolated by semi-preparative HPLC. A chemical structure of the new compound was elucidated by HPLC, LC-quadrupole time-of-flight mass spectrometry (LC-Q-TOF/MS), nuclear magnetic resonance (NMR), infrared (IR) and circular dichroism (CD) spectroscopy. The compound was identified as an acetylatedcompound of aminotadalafil. The structure of the previous unknown compound was confirmed as (6R,12aR)-2-acetamino-6-(1,3-benzodioxol-5-yl)-2,3,6,7,12,12a-hexahydro-pyrazino[1',2'1,6]pyrido[3,4-b]indole-1,4-dione and named as acetaminotadalafil.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Carbolinas
/
Suplementos Nutricionais
/
Inibidores da Fosfodiesterase 5
Tipo de estudo:
Diagnostic_studies
Idioma:
En
Revista:
Food Addit Contam Part A Chem Anal Control Expo Risk Assess
Ano de publicação:
2013
Tipo de documento:
Article