New dipyridamole salt with improved dissolution and oral bioavailability under hypochlorhydric conditions.
Drug Metab Pharmacokinet
; 28(5): 383-90, 2013.
Article
em En
| MEDLINE
| ID: mdl-23419355
ABSTRACT
The aim of this study was to develop new dipyridamole (DP) salts with pH-independent solubility for improving oral bioavailability under hypochlorhydria. Salt screening was carried out using nine counterions by the temperature gradient method. Six DP salts were obtained, and there was marked improvement in dissolution behavior for all DP salts in a neutral medium. Most DP salts were stable under accelerated conditions. On the basis of the dissolution and stability data, DP tosylate (DP/TS) was selected as a promising DP salt. The pharmacokinetics of DP and the promising DP salt were assessed in normal rats and omeprazole-treated rats as a hypochlorhydric model. After oral administration of DP/TS (10 mg-DP/kg) in normal rats, enhanced DP exposures with increased C(max) and AUC0â3 were observed compared with those with DP by ca. 2.8- and 1.7-fold, respectively. There was ca. 1 h delay of T(max) and ca. 62% reduction of AUC0â3 for DP in omeprazole-treated rats compared with those for DP in normal rats; however, oral absorption for DP/TS under hypochlorhydria was almost identical to that in normal rats. The newly developed DP/TS might provide better therapeutic efficacy in clinical use for hypochlorhydric patients.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Dipiridamol
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Drug Metab Pharmacokinet
Ano de publicação:
2013
Tipo de documento:
Article