Biodegradable IPN hydrogel beads of pectin and grafted alginate for controlled delivery of diclofenac sodium.
J Mater Sci Mater Med
; 24(5): 1179-90, 2013 May.
Article
em En
| MEDLINE
| ID: mdl-23423649
ABSTRACT
A novel diclofenac sodium (DS) loaded interpenetrating polymer network (IPN) beads of pectin and hydrolyzed polyacrylamide-graft-sodium alginate (PAAm-g-SA) was developed through ionotropic gelation and covalent cross-linking. The graft copolymer was synthesized by free radical polymerization under the nitrogen atmosphere followed by alkaline hydrolysis. The grafting, alkaline hydrolysis, and characterization of beads were confirmed by Fourier transforms infrared spectroscopy. The crystalline structure of drug after encapsulation into IPN beads were evaluated by differential scanning colorimetry and X-ray diffraction analyses. DS encapsulation was up to 96.45 %. The effect of hydrolyzed graft copolymer/pectin ratios and glutaraldehyde concentration on drug release in acidic and phosphate buffer solutions were investigated. The release of drug was significantly increased with increase of pH. The release of drug depends on the extent of cross-linking. The results indicated that IPN beads of hydrolyzed PAAm-g-SA and pectin could be used for sustained release of DS.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Anti-Inflamatórios não Esteroides
/
Diclofenaco
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Pectinas
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Hidrogel de Polietilenoglicol-Dimetacrilato
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Implantes Absorvíveis
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Implantes de Medicamento
/
Alginatos
Limite:
Animals
Idioma:
En
Revista:
J Mater Sci Mater Med
Ano de publicação:
2013
Tipo de documento:
Article