Obesity, non-alcoholic fatty liver disease, and atherothrombosis: a role for the intestinal microbiota?
Clin Microbiol Infect
; 19(4): 331-7, 2013 Apr.
Article
em En
| MEDLINE
| ID: mdl-23452186
ABSTRACT
Whereas the association between intestinal microorganisms and health has been widely accepted in the area of infectious disease, recent advances have now implied a role for the intestinal microbiota in human energy balance. In fact, numerous studies support an intricate relationship between the intestinal microbiota and obesity, as well as subsequent insulin resistance and non-alcoholic fatty liver disease. Intestinal microorganisms also seem to be involved in haemostatic tone and atherogenesis. However, as most of the findings stem from observational data, intervention studies in humans using interventions selectively aimed at altering the composition and activity of the intestinal microbiota are crucial to prove causality. If substantiated, this could open the arena for modulation of the intestinal microbiota as a future target in obesity-associated disease, both as a diagnostic test for personalized algorithms and for selective therapeutic strategies.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Trato Gastrointestinal
/
Aterosclerose
/
Metagenoma
/
Fígado Gorduroso
/
Obesidade
Limite:
Humans
Idioma:
En
Revista:
Clin Microbiol Infect
Ano de publicação:
2013
Tipo de documento:
Article