TMEDA-assisted effective direct ortho arylation of electron-deficient N-heteroarenes with aromatic Grignard reagents.
J Org Chem
; 78(7): 3243-9, 2013 Apr 05.
Article
em En
| MEDLINE
| ID: mdl-23464705
ABSTRACT
In the addition of TMEDA in toluene, aryl Grignards could effectively and site-specifically ortho-arylate electron-deficient heteroarenes under mild conditions. This endeavor successfully changed the old low-yielding reaction, aryl Grignard addition to N-heteroarenes, into an efficient procedure for heterobiaryls. The combination of the inexpensive aryl Grignards, TMEDA, the cost-free air, no use of any transition-metal catalyst, the mild reaction conditions, and the high-yielding gram-scale results enables this new procedure to be cost-effective and potentially utilizable in industry.
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1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Compostos Organometálicos
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Piridinas
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Quinolinas
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Quinoxalinas
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Etilenodiaminas
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Compostos Heterocíclicos
Idioma:
En
Revista:
J Org Chem
Ano de publicação:
2013
Tipo de documento:
Article