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Pharmacokinetics of auranofin a single dose study in man.
Benn, H P; Schnier, C; Seiler, K U; Bauer, E; Löffler, H.
Afiliação
  • Benn HP; 2nd Department of Internal Medicine, University of Kiel, West Germany.
J Rheumatol ; 17(4): 466-8, 1990 Apr.
Article em En | MEDLINE | ID: mdl-2348424
Three days after cholecystectomy 7 patients were given a single dose of auranofin (5 tablets Ridaura = 4.35 mg gold). Gold was detected in samples of blood, plasma, urine, bile and feces. The determinations were carried out using instrumental neutron activation analysis. The mean gold concentrations reached maximum in blood and plasma after 2 h and in urine and bile after 16 h. The mean terminal half-lives were 7.6 days (blood), 15 days (plasma) and 6.5 days (bile). Cumulative amounts of gold excreted in bile, urine, and feces were 1.6, 4 and 40%, respectively.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Auranofina Limite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: J Rheumatol Ano de publicação: 1990 Tipo de documento: Article
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Auranofina Limite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: J Rheumatol Ano de publicação: 1990 Tipo de documento: Article