Polymorphic variants of neurotransmitter receptor genes may affect sexual function in aging males: data from the HALS study.
Neuroendocrinology
; 98(1): 51-9, 2013.
Article
em En
| MEDLINE
| ID: mdl-23485949
ABSTRACT
BACKGROUND/AIMS:
Human behavior is influenced by a number of brain neurotransmitters. Central dopamine, serotonin and melanocortin systems have special importance for male sexual function. We searched for associations between male aging symptoms and polymorphic sites of serotonin (5-HTR1B), melanocortin (MC4R) and dopamine (DRD2, DRD4) receptors.METHODS:
In a population-based sample, genotyping of 5-HTR1B (polymorphism G861C), MC4R (polymorphisms C-2745T, Val103Ile), DRD2 (polymorphism C313T) and DRD4 (polymorphism 48-bp VNTR) was performed in 387 healthy men. The Aging Males' Symptoms (AMS) scale was used to evaluate specific ailments of aging men. We analyzed answers to questions from the AMS scale. Five points of the questionnaire addressed sexual symptoms of the aging male feeling of passing one's peak, decrease in beard growth, decrease in ability/frequency to perform sexually, decrease in the number of morning erections, and decrease in sexual desire/libido (lacking pleasure in sex, lacking desire for sexual intercourse). Relations between reported symptoms and variants of the polymorphic sites of the studied genes were assessed.RESULTS:
After adjusting for confounding factors (education, arterial hypertension, physical activity, weight, waist circumference) an association between the sexual dimension of AMS and genetic variants of 5-HTR1B G861C (p = 0.04) was observed.CONCLUSIONS:
Variability of neurotransmitter receptor genes may be associated with sexual symptoms of aging in men.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Polimorfismo Genético
/
Comportamento Sexual
/
Variação Genética
/
Envelhecimento
/
Receptor 5-HT1B de Serotonina
Tipo de estudo:
Clinical_trials
Limite:
Adult
/
Aged
/
Humans
/
Male
/
Middle aged
País/Região como assunto:
Europa
Idioma:
En
Revista:
Neuroendocrinology
Ano de publicação:
2013
Tipo de documento:
Article