Pharmacological approaches to the treatment of oxidative stress-induced cardiovascular dysfunctions.
Future Med Chem
; 5(4): 465-78, 2013 Mar.
Article
em En
| MEDLINE
| ID: mdl-23495692
ABSTRACT
Cardiovascular diseases are a growing major global health problem. Our understanding of the mechanisms of pathophysiology of cardiovascular diseases has been gaining significant advances and a wealth of knowledge implicates oxidative stress as a key causative agent. However, to date, most efforts to treat heart failure using conventional antioxidant therapies have been less than encouraging. With increasing incidences of cardiovascular disease in young as well as in aging populations, and the problem of long-term diminishing efficacy of conventional therapeutics, the need for new treatments has never been greater. In this review, [corrected] a variety of therapeutic targets and compounds applied to treat cardiovascular diseases via inhibition of oxidative stress are presented.
Texto completo:
1
Coleções:
01-internacional
Contexto em Saúde:
2_ODS3
Base de dados:
MEDLINE
Assunto principal:
Doenças Cardiovasculares
/
Sistema Cardiovascular
/
Estresse Oxidativo
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Terapia de Alvo Molecular
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Antioxidantes
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Future Med Chem
Ano de publicação:
2013
Tipo de documento:
Article