PPAR-γ agonist pioglitazone prevents apoptosis of endothelial progenitor cells from rat bone marrow.
Cell Biol Int
; 37(5): 430-5, 2013 May.
Article
em En
| MEDLINE
| ID: mdl-23504801
ABSTRACT
Selective peroxisome proliferator-activated receptor-γ (PPAR-γ) agonist affects the functions of endothelial progenitor cells (EPCs). This study explores the effect of selective PPAR-γ agonist, pioglitazone, on EPC apoptosis. The cells were cultured and identified via the double staining method in a medium containing different concentrations of pioglitazone. EPC apoptosis was detected by flow cytometry. On Day 7, EPCs engulfed DiL-ac-LDL and FITC-UEA-1, and showed yellow fluorescence in a laser-scanning confocal microscope. EPC apoptosis inhibition was maximal at 50 µmol/L. The ability of pioglitazone to prevent EPC apoptosis may be mediated by the PI3K/Akt signal pathway. The use of thiazolidine two ketone (TZD) to reduce EPC apoptosis may have some potential in treating vascular diseases.
Texto completo:
1
Coleções:
01-internacional
Contexto em Saúde:
6_ODS3_enfermedades_notrasmisibles
Base de dados:
MEDLINE
Assunto principal:
Células-Tronco
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Células da Medula Óssea
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Apoptose
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Tiazolidinedionas
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PPAR gama
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Hipoglicemiantes
Limite:
Animals
Idioma:
En
Revista:
Cell Biol Int
Ano de publicação:
2013
Tipo de documento:
Article