Cardiovascular risk factors and complications associated with albuminuria and impaired renal function in insulin-treated diabetes.
J Diabetes Complications
; 27(4): 370-5, 2013.
Article
em En
| MEDLINE
| ID: mdl-23537603
ABSTRACT
AIMS:
To establish the association between albuminuria and cardiovascular risk factors as well as micro- and macrovascular complications in type 1 and insulin-treated type 2 diabetes, both in the presence and in the absence of reduced estimated glomerular filtration rate (eGFR).METHODS:
Cross-sectional study including 7640 insulin-treated diabetic patients (33% type 1) treated in specialist diabetes centers. Albuminuria was defined as ≥30 mg/g, 20 mg/L, 20 µg/min or 30 mg/24 h. Reduced eGFR was defined as <60 mL/min/1.73 m(2) (CKD-EPI equations).RESULTS:
Albuminuria, reduced eGFR or a combination was more prevalent in type 2 (21.5%, 15.9% and 16.5%) than in type 1 diabetes (16.1%, 4.7% and 4.0%, all P < 0.001 vs. type 2). Albuminuria was associated with poorer control of blood pressure, blood lipids and glycemia as well as higher prevalence of retinopathy and macrovascular disease, regardless of preserved/reduced eGFR or diabetes type. Reduced eGFR was associated with higher prevalence of micro- and macrovascular complications especially in type 2 diabetes. Combined presence of albuminuria and reduced eGFR was associated with the worst cardiovascular outcomes.CONCLUSIONS:
Albuminuria and impaired renal function are prevalent in type 1 and insulin-treated type 2 diabetes. Albuminuria, but also normoalbuminuric renal impairment, is associated with micro- and macrovascular complications.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Doenças Cardiovasculares
/
Diabetes Mellitus Tipo 1
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Diabetes Mellitus Tipo 2
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Nefropatias Diabéticas
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Albuminúria
/
Hipoglicemiantes
/
Insulina
Tipo de estudo:
Clinical_trials
/
Etiology_studies
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Observational_studies
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Prevalence_studies
/
Risk_factors_studies
Limite:
Adult
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Aged
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Humans
/
Middle aged
Idioma:
En
Revista:
J Diabetes Complications
Ano de publicação:
2013
Tipo de documento:
Article